abstract：OBJECTIVES:To describe multiple myeloma (MM) treatment patterns and comorbidities over time in the US. RESEARCH DESIGN AND METHODS:Study patients were newly diagnosed with MM (ICD-9-CM 203.0x) between 1 July 2006 and 31 March 2014 and had ≥6 months of data prior to the initial MM diagnosis in MarketScan Research Datab...

journal_title：Current medical research and opinion

authors： Song X,Cong Z,Wilson K

更新日期：2016-01-01 00:00:00

abstract：AIMS:Disease management programs (DMP) for diabetes mellitus (DM) or coronary heart disease (CHD) address the treatment of lipid disorders. The current registry aimed to compare drug utilization, lipid lowering effects and further outcomes of outpatients at high cardiovascular risk in DMP for DM or CHD compared to pati...

journal_title：Current medical research and opinion

authors： Gitt AK,Sonntag F,Jannowitz C,Weizel A,Karmann B,Schaefer JR,Pittrow D,Hildemann SK

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To identify and compare health-economic models that were developed to evaluate the cost-effectiveness of treatments for type 2 diabetes mellitus (T2DM), and their use within Health Technology Assessments (HTAs). METHODS:In total, six commonly used databases were searched for articles published between Octobe...

journal_title：Current medical research and opinion

authors： Charokopou M,Sabater FJ,Townsend R,Roudaut M,McEwan P,Verheggen BG

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To review published evidence on the impact of weight/BMI change on health-related quality of life (HRQoL) in adults from the US with overweight/obesity. METHODS:The systematic review was conducted in accordance with PRISMA guidelines. MEDLINE, Embase, EconLit, and Cochrane Library databases were reviewed usi...

journal_title：Current medical research and opinion

authors： Kroes M,Osei-Assibey G,Baker-Searle R,Huang J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The Physician Payments Sunshine Act, enacted in 2010, is intended to increase the transparency of relationships between US physicians and teaching hospitals and manufacturers of drugs, biologics, and medical devices. We examined current opinion regarding the impact of the Sunshine Act on peer-reviewed medical...

journal_title：Current medical research and opinion

authors： Toroser D,Robinson M,Gegner J,Smith G,Nilsen J,Hyatt L,Johnson T,Hassan A,Gatchalian C

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:It is unclear how well different outcome measures in randomized controlled trials (RCTs) perform in predicting real-world cancer survival. We assess the ability of RCT overall survival (OS) and surrogate endpoints - progression-free survival (PFS) and time to progression (TTP) - to predict real-world OS acros...

journal_title：Current medical research and opinion

authors： Shafrin J,Brookmeyer R,Peneva D,Park J,Zhang J,Figlin RA,Lakdawalla DN

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to examine how lifestyle behaviors in the context of physical activity levels and screen time are associated with school absenteeism. METHODS:We analyzed 2005-2008 NHANES data of proxy interviews for 1048 children aged 6-11 years and in-person self-reports of 1117 adolescents ag...

journal_title：Current medical research and opinion

authors： Hansen AR,Pritchard T,Melnic I,Zhang J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Decision aids (DAs) are increasingly used to operationalize shared decision-making (SDM) but their development is not often described. Decisions about oral anticoagulants (OACs) for atrial fibrillation (AF) involve a trade-off between lowering stroke risk and increasing OAC-associated bleeding risk, and consi...

journal_title：Current medical research and opinion

authors： Kaiser K,Cheng WY,Jensen S,Clayman ML,Thappa A,Schwiep F,Chawla A,Goldberger JJ,Col N,Schein J

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of fenofibrate and statin dual therapy versus a double or equivalent dose of statin monotherapy. METHODS:A systematic literature search and meta-analysis was performed for publications before 1 January 2014 in MEDLINE, Embase, and BIOSIS Previews, among others. RESULTS:The difference ...

journal_title：Current medical research and opinion

authors： Ouwens MJ,Nauta J,Ansquer JC,Driessen S

更新日期：2015-12-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a major cause of morbidity and mortality and is associated with substantial healthcare costs. Identification of patients at risk of developing VTE enables appropriate thromboprophylaxis to be implemented. Although no predisposing risk factors can be identified in many patients in whom V...

journal_title：Current medical research and opinion

authors： Shirvanian S,Tapson VF

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:This subanalysis compared the efficacy of betahistine plus piracetam dual therapy versus betahistine monotherapy using data from OSVaLD, a 3 month, open-label, observational study conducted in 2272 patients with peripheral vestibular vertigo. Of the 1898 patients included in the original efficacy populatio...

journal_title：Current medical research and opinion

authors： Melnikov OA,Lilenko SV,Nauta J,Ouwens MJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Although a reduced aflibercept (2.0 mg) injection frequency relative to the approved dosing posology is included in national treatment guidelines for wet age-related macular degeneration (AMD), there is limited evidence of its comparative efficacy. The objective was to compare the efficacy and safety of reduc...

journal_title：Current medical research and opinion

authors： Szabo SM,Hedegaard M,Chan K,Thorlund K,Christensen R,Vorum H,Jansen JP

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to assess the long-term outcome of transcatheter arterial chemoembolization (TACE) after radiofrequency ablation (RFA) combined with a combined therapy for Chinese patients with intermediate (stage B) hepatocellular carcinoma (HCC) of single block type, and evaluate the survival rate...

journal_title：Current medical research and opinion

authors： Xu RC,Liu HC,Li JL,Li K,Ou SY,Yu ZY,Kong Y,Ma GA,Shao WS

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To determine the economic impact of sustained non-remission of depression on the total annual all-cause healthcare costs of patients with a history of depression. METHODS:Adults with ≥2 claims with depression diagnosis codes from the HealthCore Integrated Research Database were invited to participate in this...

journal_title：Current medical research and opinion

authors： Dennehy EB,Robinson RL,Stephenson JJ,Faries D,Grabner M,Palli SR,Stauffer VL,Marangell LB

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:As of 2012, nearly 10% of Americans had diabetes mellitus. People with diabetes are at approximately double the risk of premature death compared with those in the same age groups without the condition. While the prevalence of diabetes has risen across all racial/ethnic groups over the past 30 years, rates ar...

journal_title：Current medical research and opinion

authors： Ferdinand KC,Nasser SA

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common cancer. Most cases of BCCs are treated with only optimal surgical resection. However, unresectable, locally advanced or metastatic tumors might have potential to progress. In this patient group, there is no standardized treatment approach. Vismodegib is a new sel...

journal_title：Current medical research and opinion

authors： Erdem GU,Sendur MA,Ozdemir NY,Yazıcı O,Zengin N

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:This observational study was conducted to document the safety of capecitabine-based adjuvant therapy in patients with resected colon cancer under routine clinical conditions. RESEARCH AND DESIGN METHODS:ML20431 was a prospective, multicenter, non-interventional, observational study. It was designed to answer...

journal_title：Current medical research and opinion

authors： Steffens CC,Tschechne B,Schardt C,Jacobs G,Valdix AR,Schmidt P,Hansen R,Kröning H,Wohlfarth T,Guggenberger D

更新日期：2015-04-01 00:00:00

abstract：:The use of steroid compounds formulated in oil for depot injection can be associated with acute pulmonary reactions characterized primarily by cough, but sometimes with other associated symptoms. The pathophysiology of these reactions remains unclear, although they are reported in the literature as 'POMEs' or pulmonar...

journal_title：Current medical research and opinion

authors： Meyer RJ,Mann M

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and long-term safety of linagliptin added to basal insulin in Asian patients with type 2 diabetes mellitus (T2DM) inadequately controlled by basal insulin with/without oral agents. RESEARCH DESIGN AND METHODS:This was a post hoc analysis of Asian patients from a global ≥52 week study...

journal_title：Current medical research and opinion

authors： Sheu WH,Park SW,Gong Y,Pinnetti S,Bhattacharya S,Patel S,Seck T,Woerle HJ

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology and trends in pediatric gastrointestinal (GI) bleeding associated emergency department (ED) visits in the US. METHODS:Estimates of GI bleeding associated ED visits were calculated in children from birth to 19 years of age using the Nationwide Emergency Department Sample (NEDS). ...

journal_title：Current medical research and opinion

authors： Pant C,Olyaee M,Sferra TJ,Gilroy R,Almadhoun O,Deshpande A

更新日期：2015-02-01 00:00:00

abstract：:Although the statistical strength of direct comparative randomized controlled trials is generally acknowledged, the particular demands of therapeutic decision making will often require indirect comparisons to be made, based on pooled data from multiple trials. As for all post-hoc analyses, the process of indirect comp...

journal_title：Current medical research and opinion

authors： Belsey JD

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in patients who had switched or added a new psychiatric medication after having failed monotherapy for their psychiatric disorder. RESEARCH DESIGN AND METHO...

journal_title：Current medical research and opinion

authors： Winner JG,Carhart JM,Altar CA,Goldfarb S,Allen JD,Lavezzari G,Parsons KK,Marshak AG,Garavaglia S,Dechairo BM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Inadequate removal of extracellular volume markedly increases blood pressure and contributes to high morbidity and mortality in hemodialysis patients. Advances in fluid management are needed to improve clinical outcomes. The aim of this quality improvement project was to examine the advantages of using a hem...

journal_title：Current medical research and opinion

authors： Balter P,Ficociello LH,Taylor PB,Usvyat L,Sawin DA,Mullon C,Diaz-Buxo J,Zabetakis P

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVE:The management of hyponatremia has evolved in recent years, particularly with the introduction of tolvaptan for hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This commentary presents a summary of recent international recommendations in the for...

journal_title：Current medical research and opinion

authors： Aylwin S,Burst V,Peri A,Runkle I,Thatcher N

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the relative efficacy and safety of extended-release tramadol HCl 75 mg/acetaminophen 650 mg (TA-ER) and immediate-release tramadol HCl 37.5 mg/acetaminophen 325 mg (TA-IR) for the treatment of moderate to severe acute pain following total knee replacement. METHODS:This phase III, double-blind, p...

journal_title：Current medical research and opinion

authors： Park YB,Ha CW,Cho SD,Lee MC,Lee JH,Seo SS,Kang SB,Kyung HS,Choi CH,Chang N,Rhim HY,Bin SI

更新日期：2015-01-01 00:00:00

abstract：:In gouty patients, urate lowering therapies (ULTs) are recommended to bring serum uric acid (SUA) levels below 6.0 mg/dL, with the aim of dissolving urate depositions, thereby reducing disease impact. However, patients with hyperuricemia often present with other conditions associated with cardiovascular (CV) risk, suc...

journal_title：Current medical research and opinion

authors： Johnson RJ

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:This meta-analysis compared the median overall survival (mOS) of brentuximab vedotin reported in the pivotal phase 2 study with published results of other therapies for the treatment of relapsed/refractory (R/R) Hodgkin lymphoma (HL) post autologous stem cell transplant (ASCT). RESEARCH DESIGN AND METHODS:A ...

journal_title：Current medical research and opinion

authors： Bonthapally V,Yang H,Ayyagari R,Tan RD,Cai S,Wu E,Gautam A,Chi A,Huebner D

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To investigate the associations between obesity and any significant improvements in glycemic control, blood pressure, and lipid targets in Chinese patients with concomitant type 2 diabetes mellitus (T2DM) and hypertension. METHODS AND RESULTS:A total of 3041 dyslipidemia patients with an average age of 65.7 ...

journal_title：Current medical research and opinion

authors： Li P,Chen K,Nie Y,Guo LL,Wang HB,Wang SS,Wang AP,Hu DY,Mu YM,Li JH,DYSIS-China Study Investigators.

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic condition commonly requiring lifelong care. Both IBD and IBD-related treatments can cause significant morbidity, and it is often difficult to differentiate their relative etiologic contribution to adverse events (AEs). The objectives of this study were to assess ...

journal_title：Current medical research and opinion

authors： McAuliffe ME,Lanes S,Leach T,Parikh A,Faich G,Porter J,Holick C,Esposito D,Zhao Y,Fox I

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To compare clinical characteristics, statin treatment patterns and adherence among patients at different risk for coronary heart disease (CHD) as defined by National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines. METHODS:Patients ≥ 18 years old with ≥ 1 claim for dyslipidemi...

journal_title：Current medical research and opinion

authors： Kern DM,Balu S,Tunceli O,Anzalone D

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Over the last two decades the development and analysis of a number of registries have enhanced the knowledge of the epidemiology, presentation, natural history, and pathophysiology of pulmonary arterial hypertension (PAH). The understanding of the effectiveness of available treatments has also been greatly i...

journal_title：Current medical research and opinion

authors： Poscia R,Ghio S,D'Alto M,Vitulo P,Mulè M,Albera C,Parisi F,Badagliacca R,Fedele F,Vizza CD

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To compare the risk of developing uveitis in patients initiating anti-tumor necrosis factor (anti-TNF) agents (adalimumab, etanercept, and infliximab) for ankylosing spondylitis (AS). METHODS:Anti-TNF-naive patients with a diagnosis of AS and without a history of uveitis (N = 2115) who subsequently initiated...

journal_title：Current medical research and opinion

authors： Wendling D,Joshi A,Reilly P,Jalundhwala YJ,Mittal M,Bao Y

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In TRITON-TIMI 38, patients with acute coronary syndromes were treated with prasugrel or clopidogrel, with aspirin, for a median of 14.5 (maximum of 15) months. Based on this trial, the EU label for prasugrel recommends treatment for up to 12 months and excludes patients with prior stroke/transient ischemic ...

journal_title：Current medical research and opinion

authors： Wilcox R,Iqbal K,Costigan T,Lopez-Sendon J,Ramos Y,Widimsky P

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:In epidural analgesia, synthetic opioids increase the potency of amide local anesthetics by modifying their analgesic properties. The purpose of this systematic review and meta-analysis is to compare the efficacy and safety of bupivacaine with ropivacaine and levobupivacaine in combination with sufentanil (B...

journal_title：Current medical research and opinion

authors： Lv BS,Wang W,Wang ZQ,Wang XW,Wang JH,Fang F,Mi WD

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:To derive current real-world data on the rates and costs of severe hypoglycemia (SH) for people with type 2 diabetes mellitus (T2D) who have initiated basal insulin therapy and to examine differences in SH rates and costs stratified by history of prior SH events. METHODS:We used a nation-wide electronic hea...

journal_title：Current medical research and opinion

authors： Ganz ML,Wintfeld NS,Li Q,Lee YC,Gatt E,Huang JC

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To investigate the role of socio-economic factors on the therapeutic effectiveness of and therapeutic adherence to the angiotensin II receptor blocker (ARB) olmesartan (OM) alone or in combination with hydrochlorothiazide in the treatment of arterial hypertension. RESEARCH DESIGN AND METHODS:In a multi-cente...

journal_title：Current medical research and opinion

authors： Scholze J,Weinstock A,Kirchner F,Limberg R,Kreutz R

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:As an ever widening array of anti-hyperglycemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of a dual combination of noninsulin anti-hyperglycemic agents on lipids in type 2 diabetes. MET...

journal_title：Current medical research and opinion

authors： Dai X,Wang H,Jing Z,Fu P

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Healthcare providers managing older patients with type 2 diabetes mellitus (T2DM) face a complex milieu of medical conditions and comorbidities, which increase the risk of unintended treatment consequences. The objective of this study was to understand factors associated with hypoglycemia-related hospitalizat...

journal_title：Current medical research and opinion

authors： Fu H,Xie W,Curtis B,Schuster D

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Corticotropin-releasing hormone (CRH) is one of the most potent vasodilatory factors in the human feto-placental circulation. The expression of CRH was significantly down-regulated in patients with intrahepatic cholestasis of pregnancy (ICP). METHODS:One hundred pregnant women diagnosed with ICP at 34-34(+6)...

journal_title：Current medical research and opinion

authors： Zhou F,Zhang L,He MM,Liu ZF,Gao BX,Wang XD

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To assess the effect of an individualized genomic classifier (GC) test, for predicting metastasis following radical prostatectomy (RP), on urologists' adjuvant treatment decisions when caring for high-risk patients. PATIENTS AND METHODS:Data were submitted by US board-certified urologists in community practi...

journal_title：Current medical research and opinion

authors： Michalopoulos SN,Kella N,Payne R,Yohannes P,Singh A,Hettinger C,Yousefi K,Hornberger J,PRO-ACT Study Group.

更新日期：2014-08-01 00:00:00